abstract：PURPOSE:Chemical sphincterotomy (CS) is routinely applied in order to avoid the irreversible anal incontinence associated with the surgical treatment of chronic anal fissure (CAF). However, CS has a lower cure rate than surgery. We developed a screening test (using anal manometry) to separate those patients that are un...

journal_title：International journal of colorectal disease

authors： Gil J,Luján J,Hernández Q,Gil E,Salom MG,Parrilla P

更新日期：2010-05-01 00:00:00

abstract：PURPOSE:This study evaluates the erectile function of male patients treated by preoperative radiotherapy followed by surgery and surgery alone for locally advanced rectal cancer. METHODS:A total of 112 men treated by total mesorectal excision with autonomic nerve preservation were included. Seventy-three patients were...

journal_title：International journal of colorectal disease

authors： Song PH,Yun SM,Kim JH,Moon KH

更新日期：2010-05-01 00:00:00

abstract：BACKGROUND:For asymptomatic individuals aged 40-49 years, screening for colorectal cancer is recommended only if individuals are at an increased risk. A family history of colon cancer (FHCRC) is considered to increase risk, however, whether family history of stomach cancer (FHSC) increases the risk of adenoma is not we...

journal_title：International journal of colorectal disease

authors： Choi YS,Suh JP,Lee DS,Youk EG,Lee IT,Lee SH,Kim DS,Lee DH

更新日期：2010-04-01 00:00:00

abstract：BACKGROUND:Chemokines and their receptors have been proposed to distinctly contribute to tumor growth, dissemination, and local immune escape. The aim of this study was to evaluate the relevance of the chemokine receptor CCR5 expression for the progression of human colorectal cancer. METHODS:CCR5 expression was assess...

journal_title：International journal of colorectal disease

authors： Zimmermann T,Moehler M,Gockel I,Sgourakis GG,Biesterfeld S,Müller M,Berger MR,Lang H,Galle PR,Schimanski CC

更新日期：2010-04-01 00:00:00

abstract：OBJECTIVE/BACKGROUND:Signals for the expression of the peptide growth factors epidermal growth factor and transforming growth factor-alpha (TGFalpha) in the gastrointestinal mucosa are largely unknown. We have shown earlier that extrinsic afferents in the gastrointestinal tract induce TGFalpha expression in colonic muc...

journal_title：International journal of colorectal disease

authors： Bulut K,Felderbauer P,Hoeck K,Schmidt WE,Hoffmann P

更新日期：2010-03-01 00:00:00

abstract：PURPOSE:Deterioration of anorectal function after long-course preoperative chemoradiotherapy combined with surgery for rectal cancer is poorly defined. We conducted a prospective study to evaluate the acute and long term effects of preoperative chemoradiotherapy on anorectal function and quality of life of the patients...

journal_title：International journal of colorectal disease

authors： Canda AE,Terzi C,Gorken IB,Oztop I,Sokmen S,Fuzun M

更新日期：2010-02-01 00:00:00

abstract：PURPOSE:This study investigated whether covering the colonic anastomoses with amniotic membrane (AM) protects the anastomotic healing from the adverse effects of immediate 5-fluorouracil (5-FU) administration. METHODS:One hundred twenty wistar albino rats were randomized to one of four groups (I-IV, 30 rats in each) a...

journal_title：International journal of colorectal disease

authors： Uludag M,Ozdilli K,Citgez B,Yetkin G,Ipcioglu OM,Ozcan O,Polat N,Kartal A,Torun P,Isgor A

更新日期：2010-02-01 00:00:00

abstract：PURPOSE:Due to diagnostic advancements, preoperative staging of rectal tumors was significantly improved. However, difficulties in obtaining accurate results can sometimes be observed in the staging of adenomas and early rectal carcinomas (pT1/2). The aim of this study was to test if confocal chromolaser endomicroscopy...

journal_title：International journal of colorectal disease

authors： Borschitz T,Kiesslich R

更新日期：2010-01-01 00:00:00

abstract：PURPOSE:To verify if in large haemorrhoidal prolapse (independently from the degree) in patients with no symptoms of obstructed defaecation syndrome, the use of a stapled hemorrhoidopexy variant, comprising a double stapler haemorrhoidopexy (DSH), makes it possible to reduce the percentage of failures or relapses and t...

journal_title：International journal of colorectal disease

authors： Naldini G,Martellucci J,Talento P,Caviglia A,Moraldi L,Rossi M

更新日期：2009-12-01 00:00:00

abstract：BACKGROUND:Laparoscopic resection for the cure of rectal cancer is still a matter of debate. Laparoscopic approach is more complex and with a long learning curve, which may results in an increase in morbidity and mortality. This study aimed to retrospectively analyze the impact of laparoscopic resection for rectal canc...

journal_title：International journal of colorectal disease

authors： Hiep PN,Vu PA,Thien HH

更新日期：2009-12-01 00:00:00

abstract：OBJECTIVE:The objective of the study is to assess the efficacy of vital bulbocavernosus graft transposition in the treatment of rectovaginal fistula. MATERIALS AND METHODS:From March 2003 to October 2007, nine consecutive patients diagnosed with rectovaginal fistula were refereed to our institute. All patients were tr...

journal_title：International journal of colorectal disease

authors： Cui L,Chen D,Chen W,Jiang H

更新日期：2009-11-01 00:00:00

abstract：OBJECTIVE:The objective of this study is to assess the value of metastatic lymph node ratio (LNR) in predicting disease-free survival (DFS) in patients with stage III adenocarcinoma of the colon. MATERIALS AND METHODS:From 1995 to 2003 inclusively, a total of 624 patients featuring stage III adenocarcinoma of the colo...

journal_title：International journal of colorectal disease

authors： Chin CC,Wang JY,Yeh CY,Kuo YH,Huang WS,Yeh CH

更新日期：2009-11-01 00:00:00

abstract：PURPOSE:The aim of this study was to evaluate the clinical presentation, diagnosis and management of patients with intussusception, with special regard to the duration of symptoms, referral from other hospitals, outcome and complications related to delayed diagnosis. METHODS:This retrospective study was performed usin...

journal_title：International journal of colorectal disease

authors： Lehnert T,Sorge I,Till H,Rolle U

更新日期：2009-10-01 00:00:00

abstract：INTRODUCTION:A simple quality of life questionnaire was designed to triage patients with faecal incontinence to the most appropriate level of support, investigation and treatment. METHOD:A questionnaire was developed to include a 'symptom' score, similar in content to St Mark's questionnaire and a 'bothersome' score. ...

journal_title：International journal of colorectal disease

authors： Krysa J,Lyons M,Williams AB

更新日期：2009-10-01 00:00:00

abstract：BACKGROUND:To clarify the risk factors of lateral pelvic lymph node (LPLN) metastasis of rectal cancer, we examined associations between LPLN status and clinicopathological factors including LPLN status diagnosed by computed tomography (CT). METHODS:We reviewed a total of 210 patients with advanced rectal cancer, of w...

journal_title：International journal of colorectal disease

authors： Fujita S,Yamamoto S,Akasu T,Moriya Y

更新日期：2009-09-01 00:00:00

abstract：PURPOSE:The aim of this pilot study was to compare the performance and safety of the newly developed sodium phosphate (NaP) tablet (with and without laxatives) and polyethylene glycol (PEG), as bowel-cleansing regimens prior to colonoscopy. METHODS:A total of 35 patients were randomized to one of the following three g...

journal_title：International journal of colorectal disease

authors： Aihara H,Saito S,Arakawa H,Imazu H,Omar S,Kaise M,Tajiri H

更新日期：2009-09-01 00:00:00

abstract：PURPOSE:A cohort study was carried out to analyse quality indicators in the diagnosis and treatment of rectal carcinoma. METHODS:A total of 2,470 patients with rectal carcinoma treated between 1985 and 2007 at the Department of Surgery, University of Erlangen, were analysed and compared within four time intervals. RE...

journal_title：International journal of colorectal disease

authors： Merkel S,Klossek D,Göhl J,Papadopoulos T,Hohenberger W,Hermanek P

更新日期：2009-08-01 00:00:00

abstract：BACKGROUND:The traditional therapy for perforated sigmoid diverticulitis with peritonitis is emergency colectomy usually with colostomy. We report laparoscopic exploration with peritoneal lavage as an alternative in seven patients who required emergency surgery for diverticulitis. METHODS:Six patients presented with d...

journal_title：International journal of colorectal disease

authors： Favuzza J,Friel JC,Kelly JJ,Perugini R,Counihan TC

更新日期：2009-07-01 00:00:00

abstract：BACKGROUND:The purpose of this study was to identify clinical and pathological parameters to improve prediction of disease-free survival (DFS) and overall survival (OS) in patients treated with neoadjuvant chemoradiotherapy for rectal cancer. METHODS:Between July 1995 and May 2007, 148 patients with primary rectal ade...

journal_title：International journal of colorectal disease

authors： Moreno García V,Cejas P,Blanco Codesido M,Feliu Batlle J,de Castro Carpeño J,Belda-Iniesta C,Barriuso J,Sánchez JJ,Larrauri J,González-Barón M,Casado E

更新日期：2009-07-01 00:00:00

abstract：OBJECTIVE:The purpose of this study was to evaluate the effect of intrahepatic microvascular and lymphatic infiltration on survival in cases of colorectal liver metastases. MATERIALS AND METHODS:Prospectively collected data of 331 patients were analyzed for microvascular invasion (V), lymphatic infiltration (L), and r...

journal_title：International journal of colorectal disease

authors： Bockhorn M,Sotiropoulos G,Neuhaus J,Sgourakis G,Sheu SY,Molmenti E,Fingas C,Trarbach T,Frilling A,Broelsch CE

更新日期：2009-07-01 00:00:00

abstract：BACKGROUND AND AIMS:Endoscopic polypectomy still remains the cornerstone of therapy for colorectal polyps and adenomas. However, if colorectal polyps are too large or not accessible for endoscopic ablation or cannot be removed without an increased risk for perforation, operative procedures are required. In such circums...

journal_title：International journal of colorectal disease

authors： Hauenschild L,Bader FG,Laubert T,Czymek R,Hildebrand P,Roblick UJ,Bruch HP,Mirow L

更新日期：2009-07-01 00:00:00

abstract：BACKGROUND:Tight junction (TJ) proteins play a critical role in cellular adhesion, glandular differentiation, and cellular proliferation. The function of these proteins is compromised in a number of intestinal diseases, including ulcerative colitis that has an increased incidence for colorectal carcinoma (CAC). The aim...

journal_title：International journal of colorectal disease

authors： Mees ST,Mennigen R,Spieker T,Rijcken E,Senninger N,Haier J,Bruewer M

更新日期：2009-04-01 00:00:00

abstract：AIM:The present study aims to evaluate and compare the efficacy of two nitrate gels, containing isosorbide-5-mononitrate (ISMN) or glyceryl trinitrate (GTN), in the therapy of chronic anal fissure. MATERIALS AND METHODS:The patients were randomly assigned to three groups: 0.1% ISMN gel (21 patients), 0.1% GTN gel (21 ...

journal_title：International journal of colorectal disease

authors： Tankova L,Yoncheva K,Kovatchki D,Doytchinova I

更新日期：2009-04-01 00:00:00

abstract：BACKGROUND:Genetic variability in obesity-related genes and the resulting phenotypes are being recognized as major risk factors for colorectal cancer and/or severity of the disease. MATERIALS AND METHODS:A total of 102 patients (aged 68 +/- 10.2 years, 79 men and 23 women) and 101 age-matched (68.1 +/- 5.4 years old) ...

journal_title：International journal of colorectal disease

authors： Vasků A,Vokurka J,Bienertová-Vasků J

更新日期：2009-03-01 00:00:00

abstract：AIM:An illustration of the diagnosis and management of tailgut cysts. MATERIALS AND METHODS:Two cases of tailgut cyst and a review of the literature. RESULTS:A female patient presented with acute urinary retention with a retrorectal mass felt during rectal examination and confirmed on ultrasound and magnetic resonanc...

journal_title：International journal of colorectal disease

authors： Au E,Anderson O,Morgan B,Alarcon L,George ML

更新日期：2009-03-01 00:00:00

abstract：BACKGROUND:Preclinical and clinical evidence support an association between vitamin D deficiency and an increased risk of colorectal cancer. Normal vitamin D status has been linked to favorable health outcomes ranging from decreased risk of osteoporosis to improved cancer mortality. We performed a retrospective study t...

journal_title：International journal of colorectal disease

authors： Fakih MG,Trump DL,Johnson CS,Tian L,Muindi J,Sunga AY

更新日期：2009-02-01 00:00:00

abstract：BACKGROUND:To evaluate the value of positron emission tomography using fluorodeoxyglucose and computer tomography scan (FDG-PET/CT) for prediction of histopathological response of preoperative radiochemotherapy (RCTX) in patients with rectal carcinoma. METHODS:Thirty patients with uT3 rectal carcinoma were examined by...

journal_title：International journal of colorectal disease

authors： Rosenberg R,Herrmann K,Gertler R,Künzli B,Essler M,Lordick F,Becker K,Schuster T,Geinitz H,Maak M,Schwaiger M,Siewert JR,Krause B

更新日期：2009-02-01 00:00:00

abstract：BACKGROUND AND AIMS:Information about faecal calprotectin (FC) in colonic diverticular disease (DD) are lacking. We assessed FC in colonic DD, comparing it with irritable bowel syndrome (IBS) patients and healthy controls. Moreover, we compared FC levels in different degrees of DD and assessed FC in symptomatic DD befo...

journal_title：International journal of colorectal disease

authors： Tursi A,Brandimarte G,Elisei W,Giorgetti GM,Inchingolo CD,Aiello F

更新日期：2009-01-01 00:00:00

abstract：AIM:The aim of this experimental study was to investigate the effect of intraperitoneal administration of oxaliplatin on the healing of colonic anastomoses when injected immediately after colon resection. MATERIALS AND METHODS:Thirty male Wistar rats were used. During the operation, the rats were randomized to two gro...

journal_title：International journal of colorectal disease

authors： Kanellos D,Pramateftakis MG,Demetriades H,Zacharakis E,Angelopoulos S,Mantzoros I,Kanellos I,Despoudi K,Zaraboukas T,Koliakos G,Galovatsea K,Lazaridis H

更新日期：2008-12-01 00:00:00

abstract：BACKGROUND AND AIMS:The perioperative use of a single course adjuvant portal vein infusion chemotherapy in patients with potentially curable colorectal cancer has been shown to significantly improve overall survival but did not reduce the occurrence of liver metastases (SAKK 40/81) [Swiss Group for Clinical Cancer Rese...

journal_title：International journal of colorectal disease

authors： Laffer U,Metzger U,Aeberhard P,Lorenz M,Harder F,Maibach R,Zuber M,Herrmann R

更新日期：2008-12-01 00:00:00

abstract：BACKGROUND:Extramammary Paget's disease (EMPD) most commonly occurs in the perineal and genital areas of elderly people. The current treatment of choice is adequate surgical excision. MATERIALS AND METHODS:Between 1990 and 2007, 28 patients (27 men and one woman) with EMPD were treated at Asan Medical Center, Seoul, K...

journal_title：International journal of colorectal disease

authors： Yoon SN,Park IJ,Kim HC,Yu CS,Lee MW,Koh JK,Kim JW,Park YS,Kim JC

更新日期：2008-11-01 00:00:00

abstract：PURPOSE:Fecal incontinence (FI) is a debilitating condition that can be socially and personally incapacitating. A broad range of treatment options, often stepwise, are available, depending on severity. This prospective study reports a large single-centered series of patients who have benefited of temperature-controlled...

journal_title：International journal of colorectal disease

authors： Lefebure B,Tuech JJ,Bridoux V,Gallas S,Leroi AM,Denis P,Michot F

更新日期：2008-10-01 00:00:00

abstract：BACKGROUND AND AIMS:This study used postoperative defecography to characterize morphological features of defecatory disorders in patients following rectal resection. We also evaluated differences in dynamic defecatory condition depending on reconstruction methods for sphincter-saving surgery. MATERIALS AND METHODS:Sub...

journal_title：International journal of colorectal disease

authors： Morihiro M,Koda K,Seike K,Miyauchi H,Miyazaki M

更新日期：2008-09-01 00:00:00

abstract：PURPOSE:The Bethesda guidelines suggest to perform microsatellite instability (MSI) test in early onset rectal cancer and not in patients>50 years with proximal colon cancer. The aim of the study was to evaluate whether the risk of high MSI (MSI-H) is greater in proximal colon cancer of patients 51-60 years old than in...

journal_title：International journal of colorectal disease

authors： Urso E,Pucciarelli S,Agostini M,Maretto I,Mescoli C,Bertorelle R,Viel A,Rugge M,Nitti D

更新日期：2008-08-01 00:00:00

abstract：AIMS:Our aim was to investigate whether the dynamic and static compliances differ between patients with irritable bowel syndrome (IBS) and normal subjects. MATERIALS AND METHODS:Fifty-five IBS patients (age range 20-65 years, mean age 39.0 years, 28 women and 27 men; 36 diarrhea-predominant IBS (IBS-D) patients and 19...

journal_title：International journal of colorectal disease

authors： Park JH,Baek YH,Park DI,Kim HJ,Cho YK,Sohn CI,Jeon WK,Kim BI,Rhee PL

更新日期：2008-07-01 00:00:00

abstract：BACKGROUND:The clinicopathological roles and relationships of hTERT, p21 and p53 proteins have not been studied in depth in colorectal cancer. The aim of the present study is to investigate the clinicopathological roles of expression of hTERT protein expression and its relationship with the expression of p21 and p53 pr...

journal_title：International journal of colorectal disease

authors： Lam AK,Ong K,Ho YH

更新日期：2008-06-01 00:00:00

abstract：BACKGROUND:The prognostic significance of anti-53 autoantibody in colorectal cancer (CRC) patients is unclear due to measurement of overall rather than disease-specific survival and generally short follow-up periods in many studies. We aim to investigate prognostic significance of anti-p53 auto-antibodies in a study wi...

journal_title：International journal of colorectal disease

authors： Suppiah A,Alabi A,Madden L,Hartley JE,Monson JR,Greenman J

更新日期：2008-06-01 00:00:00

abstract：BACKGROUND AND AIMS:Accurate, long-term risk predictors for colorectal cancer development in patients with sporadic adenomas are lacking. We sought to validate biomarkers predictive of metachronous colorectal cancer (mCRC) in patients with sporadic colorectal adenomas, using 374 consecutive patients from a large define...

journal_title：International journal of colorectal disease

authors： Søreide K,Gudlaugsson E,Skaland I,Janssen EA,Van Diermen B,Körner H,Baak JP

更新日期：2008-04-01 00:00:00

abstract：BACKGROUND:Anastomotic leakage is a major concern after resection for low rectal cancer. Therefore, the use of a defunctioning stoma (DS) has been suggested, but limited data exist to clearly determine the necessity of a routine diversion. In our department, the indication of DS was evaluated subjectively by the operat...

journal_title：International journal of colorectal disease

authors： Lefebure B,Tuech JJ,Bridoux V,Costaglioli B,Scotte M,Teniere P,Michot F

更新日期：2008-03-01 00:00:00

abstract：BACKGROUND:Anastomotic dehiscence is the most severe surgical complication after large bowel resection. This study was designed to assess the incidence, to observe the consequences, and to identify the risk factors associated with anastomotic leakage after colorectal surgery. MATERIALS AND METHODS:All procedures invol...

journal_title：International journal of colorectal disease

authors： Buchs NC,Gervaz P,Secic M,Bucher P,Mugnier-Konrad B,Morel P

更新日期：2008-03-01 00:00:00